CIPLA LTD. (INDIA)

Abiraterone acetate-xbira

“Abiraterone Acetate” is the Drug / Molecule content in “Xbira”. Abiraterone belongs to the general class of drugs known as hormones or hormone antagonists. Abiraterone works by blocking an enzyme called CYP17. This enzyme normally helps certain cells in the body make male hormones called androgens, such as testosterone. Since prostate cancer usually depends on androgens to help it grow and spread, this helps stop it from growing.

Details
Specification

Indication

Abiraterone acetate is used in combination with prednisone, a corticosteroid to treat metastatic castration-resistant prostate cancer and in the treatment of metastatic high-risk castration-sensitive prostate cancer.

Note

SIDE EFFECTS :

Common side effects include headache, nausea, rash, diarrhea, fatigue, urinary tract infection, hypertension, cough hypokalemia, glucocorticoid deficiency.

INTERACTIONS :

Abiraterone acetate is a CYP3A4 substrate and hence should not be administered concurrently with strong CYP3A4 inhibitors such as Ketoconazole, Itraconazole, Clarithromycin, Atazanavir, Nefazodone, Saquinavir, Telithromycin, Ritonavir, Indinavir, Nelfinavir, Voriconazole or inducers such as Phenytoin, Carbamazepine, Rifampin, Rifabutin, Rifapentine, Phenobarbital
Spironolactone should be avoided in prostate cancer patients suffering from treatment-associated mineralocorticoid side effects of Abiraterone acetate.

OVERDOSE :

Clinical experience with overdose of Abiraterone acetate is limited. There is no specific antidote for Abiraterone acetate overdose, and treatment should consist of general supportive measures, including monitoring of cardiac and liver function.

Precaution

Abiraterone acetate is a prescription drug and should be used under proper medical guidance and advice.
Abiraterone acetate is not for use in women or children.

Updated On Oct 23, 2019 by Admin