Dabur Pharmaceuticals Ltd

Amiphos

"Amiphos" contains Drug / Molecule called “Amifostine”. Amiphos is a cytoprotective adjuvant used in cancer chemotherapy involving DNA-binding chemotherapeutic agents.

Amifostine is an organic thiophosphate prodrug which is hydrolysed by alkaline phosphatase to the active cytoprotectivethiol metabolite. The selective protection of non-malignant tissues is believed to be due to higher alkaline phosphatase activity, higher pH, and vascular permeation of normal tissues.

Details
Specification

Indication

Amiphos is used therapeutically to reduce the incidence of neutropenia-related fever and infection induced by DNA-binding chemotherapeutic agents including alkylating agents (e.g. cyclophosphamide) and platinum-containing agents (e.g. cisplatin). It is also used to decrease the cumulative nephrotoxicity associated with platinum-containing agents. Amiphos is also indicated to reduce the incidence of xerostomia in patients undergoing radiotherapy for head and neck cancer.

Note

Precaution

Amiphos is a prescription drug and should be used under proper medical guidance and advice.
Hypotension during infusion.
Caution when used during Pregnancy and Lactation.

Updated On Oct 18, 2019 by Admin

Strength

300 mg, 500 mg.

Packing

Vial

Storage

Store at 20-25°C (Vials containing lyophilized powder for IV). Reconstituted solution: Stable at room temperature (25°C), for 5 hrs. OR Store between 2-8°C) for 24 hr.