Gilead Science, INC
Harvoni-hepcinat lp
"Harvoni" contains the Drugs / Molecules called “Ledipasvir & Sofosbuvir”. It is a fixed-dose combination of ledipasvir and sofosbuvir which are direct acting antiviral agents against the hepatitis C virus (HCV). Ledipasvir is an inhibitor of the protein, which is required for viral replication. Sofosbuvir is a nucleotide prodrug that undergoes intracellular metabolism to form the pharmacologically active uridine analog triphosphate which can be incorporated into HCV RNA and acts as a chain terminator.
Indication
Harvoni is used for the treatment of chronic hepatitis C virus (HCV).
Cure rates are 94% to 99% in people infected with genotype 1 (46% of HCV cases). It has also been evaluated for the treatment of infection with other Hepatitis C genotypes, and has shown promising results in genotypes 3 and 4.
Note
SIDE EFFECT :
- Common side effects include muscle pains, headache, nausea, rash, diarrhea, insomnia and cough.
- More severe reactions are connected with allergic reactions to the medications and cardiovascular problems.
INTERACTIONS :
- Patients are advised to stay away from H2 Receptor Antagonists (H2RA) and Proton Pump Inhibitors (PPI) because they decrease the concentration of Ledipasvir.
- Ledipasvir / Sofosbuvir should additionally be avoided when taking Amiodarone or other drugs that lower heart rate; there is a serious risk of the heart slowing or stopping when Ledipasvir / Sofosbuvir is used with such drugs.
OVERDOSE :
- Do not use more than prescribed dose.
- If you suspect you may have overdosed, call your healthcare provider.
- Do not take extra dose to make up for the missed dose.
Precaution
- Harvoni is a prescription drug and should be used under proper medical guidance and advice.
- Do not use Harvoni if you are pregnant or breastfeeding or trying to get pregnant.
- Harvoni is contradicted for use during unprotected sexual intercourse as it may also lead to birth defects.
Updated On Oct 26, 2019 by Admin
Strength
90 mg Ledipasvir / 400 mg Sofosbuvir
Packing
1 X 28 Tablets (Plastc Container)
Storage
Store at a Temperature not exceeding 30 C
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Harvoni-hepcinat lp also available as
NATCO PHARMA LIMITED (INDIA)
Hepcinat-lp
“Hepcinat-LP” is a fixed-dose combination of “Ledipasvir and Sofosbuvir” which are direct acting antiviral agents against the hepatitis C virus (HCV). Ledipasvir is an inhibitor of the protein, which is required for viral replication. Sofosbuvir is a nucleotide prodrug that undergoes intracellular metabolism to form the pharmacologically active Uridine analog triphosphate which can be incorporated into HCV RNA and acts as a chain terminator.