JANSEEN PHARMACEUTICAL CO.
Zytiga-xbira
“Zytiga” contains the Drug / Molecule called “Abiraterone Acetate”. Zytiga belongs to the general class of drugs known as hormones or hormone antagonists. It works by blocking an enzyme called CYP17. This enzyme normally helps certain cells in the body make male hormones called androgens, such as testosterone. Since prostate cancer usually depends on androgens to help it grow and spread, this helps stop it from growing.
“Xbira” is the generic version of “Zytiga” and both contains same drug “Abiraterone Acetate”.
Indication
Zytiga is used in combination with prednisone, a corticosteroid to treat metastatic castration-resistant prostate cancer and in the treatment of metastatic high-risk castration-sensitive prostate cancer.
Note
SIDE EFFECTS :
- Common side effects include headache, nausea, rash, diarrhea, fatigue, urinary tract infection, hypertension, cough hypokalemia, glucocorticoid deficiency.
INTERACTIONS :
- Abiraterone acetate is a CYP3A4 substrate and hence should not be administered concurrently with strong CYP3A4 inhibitors such as Ketoconazole, Itraconazole, Clarithromycin, Atazanavir, Nefazodone, Saquinavir, Telithromycin, Ritonavir, Indinavir, Nelfinavir, Voriconazole or inducers such as Phenytoin, Carbamazepine, Rifampin, Rifabutin, Rifapentine, Phenobarbital
- Sprironolactone should be avoided in Prostate Cancer patients suffering from treatment-associated mineralocorticoid side effects of Abiraterone acetate.
OVERDOSE :
- Clinical experience with overdose of Zytiga is limited. There is no specific antidote for Zytiga overdose, and treatment should consist of general supportive measures, including monitoring of cardiac and liver function.
Precaution
- Zytiga is a prescription drug and should be used under proper medical guidance and advice.
- Zytiga is not for use in women or children.
- Zytiga should be swallowed whole with water and not to be crushed or chewed.
Strength
250 mg
Packing
1 X 120 Tablets (Plastic Container)
Storage
Store at room temperature
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Zytiga-xbira also available as
CIPLA LTD. (INDIA)
Xbira
“Xbira” contains the Drug / Molecule called “Abiraterone”. Xbira belongs to the general class of drugs known as hormones or hormone antagonists. Xbira works by blocking an enzyme called CYP17. This enzyme normally helps certain cells in the body make male hormones called androgens, such as testosterone. Since prostate cancer usually depends on androgens to help it grow and spread, this helps stop it from growing.